ONCOLille’s Biology platform has broad-ranging areas of expertise. It provides support to research programmes, and facilitates the interface between researchers at ONCOLille and 5 technical platforms which enable priority access to very high-performance analysis methods for tumour cells and tumour samples.
Located in the biological resources centre of the Lille CHRU, and forming part of a network with 28 other national platforms, these two services are devoted exclusively to cancerology. Also, all the ONCOLille research projects have direct access to it.
Over 80 % of its activities are devoted to identifying genetic and genome damage in haematopoietic tumours (Dormancy Orientation) and solid tumours (Resistance Orientation). Thirty or so ONCOLille research projects benefit from the services of the genomics platform.
Approximately 20 % of its time is devoted to oncology projects. With an IBISA (Biology, Health & Agronomy Infrastructures) quality label providing testimony to its excellence, quite often it is a central factor in resolving ONCOLille’s specific scientific issues through very precise identification of the proteins (4,000 proteins, 20,000 peptides) present in tumours. It is also capable of identifying particular modifications to molecules (deamination, oxidation, phosphorylation, etc.) which is crucial for understanding pathological mechanisms within tumour cells.
Approximately 40 % of its activities are devoted to research projects in the field of cancerology (most of which are linked to ONCOLille’s activities). Bolstered by its expertise in the chemistry of peptides, this platform works in association with certain ONCOLille projects on the development of specific inhibitors of receptors and enzymes involved in the tumour process.
With ONCOLille’s support, new pieces of equipment have been acquired in order to reinforce certain platforms such as Functional and Structural Genomics through, for example, purchasing an Ion Proton high-throughput sequencer, which is essential for the two orientations’ projects.
Four design and research engineers have been assigned the mission of developing new activities within this Biology platform directly linked to ONCOLille’s research programmes:
This strategy, involving direct integration of engineers into the research teams, offers very high added value for technological developments.